Diagnostic Approaches – 1

For a doctor, diagnosis is the cornerstone of their work. Patients do not come to doctors with a sticker on their face that tells what their illness is. However, people often assume that the doctor should immediately know the precise nature of the illness as soon as they see the patient. Sometimes this is possible. The patient’s walk, demeanor, fatigue, smile, appearance, and voice can sometimes provide critical clues about the disease. In such situations, diagnosing can be relatively simple. However, at other times, the process of diagnosis can be as difficult as searching for a needle in a haystack. A doctor is like a police officer investigating a crime. Just as the police officer questions many people, a doctor might ask the patient and their family many questions repeatedly. Just as the police collect evidence, the doctor examines the patient’s body for evidence. The goal is to gather the necessary information for diagnosis.
By this stage, the doctor’s mind will likely have a list of possible illnesses. To determine the exact one, lab tests, scans, other tests, and consultations with other doctors may be needed. After all of this, clarity will often emerge regarding the illness. Depending on the nature of the disease, the number of tests required, their cost, and time may vary.
However, there are rare instances where, even after all these steps, a complete clarity about the illness is not reached. These cases present a significant challenge for doctors. Sometimes, the patient will need to be seen repeatedly at specific intervals. This is called a "follow-up." It is during these follow-up visits that the illness may reveal its true form and the correct diagnosis can be made.
Sometimes, a bit of luck is also needed for a diagnosis. Luck may come in many forms—critical information that suddenly emerges, thoughts that come to the mind, or significant observations that appear before the doctor’s eyes. These moments sometimes guide the doctor to the correct path. Such occurrences will be discussed in a few follow-up articles.
I remember during my early days at the clinic, a friend called me to confirm if I would be available the next day for an OP visit. The patient was a relative of a friend, and they were coming from a long distance. After confirming that I would be there, the friend mentioned that the patient had been to many other doctors without any improvement. The patient seemed to be in a state of constant fatigue, with no interest in work, and no enthusiasm for anything. The friend mentioned that the patient had seen many doctors, but nothing had helped.
I felt a sense of responsibility when hearing about the patient. The expectation from me would be high, as the patient had been to several other doctors already. I started gathering the basic information about the patient, thinking that if another doctor had already seen the case, there would be no need for them to come to me.
“What’s the illness?” I asked.
“Oh, nothing specific,” the friend replied. “He’s been tired for years. No interest in anything. His body is weak, and he’s not interested in going to work. He feels constantly fatigued and drained.”
I thought to myself, this could be a simple case, but maybe the patient’s condition was beyond my expertise. Nevertheless, I decided to see the patient.
Before ending the call, the friend unexpectedly shared something critical. The patient had been bitten by a snake a few years ago and had almost died. He had spent a long time in the Kozhikode Medical College due to kidney failure and had undergone several dialysis sessions before being saved. Since then, he had no issues, until now.
This information was extremely important in this case, as it opened the path for the diagnosis. Without this information, the illness may have gone undiagnosed or taken much longer to detect.
People who have been in critical conditions, like a snake bite, often face problems with the pituitary gland in the brain. This condition can take several years to show symptoms. When the pituitary gland doesn’t function properly, it affects the thyroid, adrenal glands, and sex hormone production. This results in a lack of interest in anything, fatigue, and even reduced sexual desire.
Although rare, I had seen a similar case during my MBBS training in Thrissur Medical College and later during my MD studies in Kozhikode.
By the next day, I was able to make a diagnosis of the patient’s condition. After conducting hormone tests, it was confirmed. With hormone therapy, the patient began to recover and regained his strength after a few weeks.
It was a crucial piece of information from a relative that helped me find the right diagnosis. At times, a bit of luck and timely information are needed for both the doctor and the patient.
 

Diagnostic Approaches – 2
This story is about a college student who came in with a fever. It's an illness that's easy to understand without too much confusion or stress. However, there are certain facts that everyone should be aware of, which is why this case was chosen.
The student had a high fever along with mild diarrhea, nausea, and a headache. Initial examinations made it seem like typhoid. To confirm if that's the case, a blood culture test was done, and the patient was admitted, starting antibiotic injections. The report would take three days to arrive. However, waiting until then wasn't an option. The treatment started based on clinical diagnosis. Later, when the report arrived, it would confirm if it was indeed typhoid and whether the current medication was effective or if any adjustments were needed.
If the correct medication is started for typhoid fever, it will take about 3-4 days for the fever to decrease. I made sure to explain this to them beforehand, as otherwise, they might repeatedly ask the doctor, causing unnecessary stress. After all, there’s always someone who will wonder, even after receiving the medication, why the fever isn't decreasing.
After three days, the intensity of the fever had reduced. The blood test report still hadn't come in. The following day, since the patient had planned to take a ten-day leave for a trip to the UAE, I discharged him along with others who were ready for discharge. I switched the antibiotic injections to tablets and reminded him that even after returning home, the fever might persist for another day or two, but there was no need to worry as long as the medication continued. He agreed and left for home.
After his trip, he returned to the clinic. His face didn’t show much of a change. When I asked about it, he started speaking in an accusatory tone.
"I told you, the fever could last another day or two."
"We went straight to a hospital in Thrissur," he said. "You can’t just deal with a fever like this."
"Okay, what did they say?"
"Well, that’s why we came here. The doctor here said it wasn’t typhoid, but a common viral fever."
That was the issue. They were implying that I had treated a non-existent illness. Many people believe that the final word comes from doctors at big hospitals, and there's a general societal assumption that their advice is always superior.
The patient's blood test results had already been communicated to me by the lab. I didn’t say anything further to them. I told them, "Your blood test report is ready in the lab. Please pick it up and come here."
When they brought the report, I asked them to open and read it. He read aloud:
“Salmonella Typhi Isolated.”
I asked, “Doesn’t that mean that Salmonella Typhi has been isolated from your blood?”
He nodded in agreement.
"Right, this is the bacteria that causes the disease we call typhoid."
At this, both the father and son were taken aback, their accusatory expressions slowly turning into ones of understanding and sympathy.
"I explained everything to you in detail that day. If you had been patient for a day or two, we might have avoided the need for another admission at a different hospital."
Without saying anything more, both of them quietly left.
All doctors working in small hospitals will experience such situations. A doctor's abilities depend on several factors—enthusiasm shown during study, sincerity, clinical exposure during training, the competence of the teachers, dedication after completing studies, efforts to keep up with new developments, and communication with doctors from other specialties, all of which influence a doctor's skills. However, there is no significant connection between the size of the hospital and a doctor's competence. In a smaller hospital, you might find doctors with lesser skills as well, and just working in a larger building doesn't increase a doctor's knowledge and abilities.
This way of thinking leads to certain problems. Some people tend to show unhealthy levels of obedience to diagnoses and advice given by doctors in big hospitals. If the diagnosis is 100% correct, that kind of obedience might be fine. However, all doctors are human, and even famous doctors can sometimes make mistakes in diagnosis. Perhaps later, a doctor in a smaller hospital may make the correct diagnosis or suggest certain tests that were missed before. At that time, if a patient says, "This is the disease as the doctor said, they’ll take care of it," and insists that the treatment from the new doctor is sufficient, they might be shutting the door to proper diagnosis and treatment.
Let me give two examples. Once, a patient who had been diagnosed with liver cirrhosis (liver inflammation) by a gastroenterologist came to our hospital. The doctor had advised a blood transfusion because the patient's blood count was low. Upon reviewing the old reports, I couldn’t find any evidence confirming that the problem was liver-related. However, after examining the patient, I noticed symptoms of blood cancer. I discussed my doubts with the patient's son, and fortunately, he agreed to further tests. After conducting a bone marrow test, we confirmed blood cancer. Unfortunately, due to the delay in diagnosis and the patient’s age, we couldn’t save the patient.
In another case, a patient who had previously been diagnosed with epilepsy and was taking medication, came to the clinic because of recurring symptoms. After questioning, I suspected that the patient’s condition was actually syncope, a type of fainting caused by heart issues. After checking the patient’s pulse, I found it was dangerously low, indicating a complete heart block. We then implanted a pacemaker, which resolved the patient’s issues with fainting.
The point here is that no one’s word should be considered the final word. When visiting a doctor, go with an open mind, free of prejudices. Be sure to share your symptoms and treatment details honestly with the doctor. If the doctor raises any doubts, listen to them carefully rather than dismissing them. Don’t dismiss the doctor by saying, "I’ve already been treated by another doctor," especially when it comes to complicated matters. In the end, it’s important to keep an open mind and even consult with the previous doctor if needed.
Let me end with an example from when I worked in an emergency department right after completing my MBBS. A retired soldier came to the hospital in the middle of the night with his son. When I asked what the problem was, he gave a very strange complaint.
“Doctor, my heart rate is 90.”
“What’s the problem with that? Do you have chest pain or difficulty breathing?” I asked.
“No, nothing like that.”
“Then there’s no problem with a heart rate of 90,” I replied.
“No, I’m a heart attack patient. My doctor told me that my heart rate should be between 65-70. I check it many times a day, and it never goes up to 90.”
“65-70 might be better for you, but it doesn’t mean that anything above that is an illness. The human body isn’t a machine, and your physical activity, mental stress, etc., all influence your heart rate. Checking your pulse frequently like this will only cause unnecessary stress, which will increase your heart rate. Stop checking it constantly and enjoy the beauty and peace of life,” I said.
He was very upset and replied, “You don’t know anything. My doctor has told me about heart rate. What do you know?”
I was frustrated by his response. The son tried to calm him down, gently persuading him, and gave me an apologetic look. Then the patient stormed out, angrily stomping his feet on the floor.
It’s true that heart rate should be kept at a lower level after a heart attack, and the doctor explained this to him. But because of his excessive obedience to his previous doctor, he was not willing to listen to anything else.
The lesson here is clear: keep an open mind, listen to the doctor, and don’t blindly follow any advice.
 

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